G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth
GPER expression in xenografts of Ishikawa H cells and Hec50 endometrial cancer cells as well as representative type I and type II human primary tumors. (a)–(e) Immunohistochemical staining of GPER in xenograft tumors of Ishikawa H cells ((a), 20x; (b), 40x) demonstrating the areas most strongly positive for GPER, and representative xenograft tumors of Hec50 cells ((d), 20x; (e), 40x; (c), negative control (irrelevant primary antibody), 40x). ((f)–(h)) GPER staining of a recurrent adenocarcinoma with endometrioid features ((f), mouse xenograft of patient tumor, 40x; (g), patient tumor, 40x; (h), patient tumor, 20x, demonstrating focal positivity; (i), ER and PR (inset) staining of the same patient tumor). ((j)–(l)) GPER staining from a patient with Stage IA carcinosarcoma ((j), mouse xenograft of patient tumor, 20x, illustrating diffuse positive staining in both epithelial and stromal fractions; (k), patient tumor, 40x; (l), patient tumor, 20x, demonstrating similarly strong GPER staining in both the epithelial and stromal compartments).
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