Research Article

G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth

Figure 7

Inhibition of Hec50 tumor growth by GPER antagonist. Hec50 cell tumors were initiated in ovariectomized athymic mice and treated with a slow release pellet containing either no added compound (sham), estrogen (E2), G-1, or with two pellets (one of estrogen and one of G36, E2 + G36). (a) Tumor volume was measured with calipers over a 24-day period. (b) Upon sacrifice, tumors were dissected and tumor mass was determined. Data represent mean s.e.m. from 6–8 mice. * versus sham; # versus E2 alone. Note that the tumor size for E2 + G36 was not significantly different from the sham.
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(a)
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(b)