The Natural History of Uterine Leiomyomas: Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation

Figure 12

Injury and autophagy. A cluster of degenerating mitochondria (long arrows) near the center of the image are swollen and show fragmentation and loss of cristae. The myofilaments of the surrounding cytoplasm also appear granular and degenerate. To the right of the mitochondria, there is vacuole, probably autophagic, containing membranous debris (short arrow). The image suggests that the degenerate mitochondria and myofilaments are being drawn into an autophagic vacuole. Original magnification: 20,500x.