Research Article
The Natural History of Uterine Leiomyomas: Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation
Table 4
Comparison of necrosis, apoptosis, and inanosis.
| ā | Necrosis (ischemic) | Apoptosis | Inanosis |
| Basic mechanism | Energy independent | Energy-dependent | Energy independent | Speed of Process | Rapid | Rapid | Slow | Individual cell versus groups of cells | Usually groups | Individual | Individual | Typical pattern | Regional groups of cells | Individual cells | Mottled (interspersed viable cells) | Histologic hallmark | Zonal (multicellular) coagulative necrosis | Apoptotic nuclear changes; tingible body macrophages | Myocyte tombstone | Nuclear changes | Pyknosis, karyorrhexis, or karyolysis | Pyknosis and karyorrhexis | Shrinkage and pallor | Cytoplasmic volume | Cell swelling | Cell shrinkage | Cell shrinkage | Cytoplasmic shape | Variable | Rounded | Normal | Cytoplasmic tinctorial features | Hypereosinophilic | Hypereosinophilic | Pallor | Relation of cell to adjacent cells or stroma | Variable | Detaches from neighboring cells | Maintains connection initially | Inflammation | Usually | No; macrophages | No | Disposition of dead cells | Phagocytosis | Phagocytosis | Gradual dissolution (Reclamation) | Release of cytoplasmic contents | Yes | No | Yes |
|
|