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Obstetrics and Gynecology International
Volume 2013 (2013), Article ID 892465, 8 pages
http://dx.doi.org/10.1155/2013/892465
Review Article

Lymph Node Assessment in Endometrial Cancer: Towards Personalized Medicine

1Stem Cell and Microenvironment Laboratory, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar
2Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
3Department of Genetic Medicine and Obstetrics and Gynecology, Weill Cornell Medical College, Stem Cell and Microenvironment Laboratory Weill Cornell Medical College in Qatar, Qatar Foundation, Doha 24144, Qatar

Received 15 April 2013; Accepted 28 August 2013

Academic Editor: Peter E. Schwartz

Copyright © 2013 Fabien Vidal and Arash Rafii. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Endometrial cancer (EC) is the most common malignancy of the female reproductive tract and is increasing in incidence. Lymphovascular invasion and lymph node (LN) status are strong predictive factors of recurrence. Therefore, the determination of the nodal status of patients is mandatory to optimally tailor adjuvant therapies and reduce local and distant recurrences. Imaging modalities do not yet allow accurate lymph node staging; thus pelvic and aortic lymphadenectomies remain standard staging procedures. The clinical data accumulated recently allow us to define low- and high-risk patients based on pre- or peroperative findings that will allow the clinician to stratify the patients for their need of lymphadenectomies. More recently, several groups have been introducing sentinel node mapping with promising results as an alternative to complete lymphadenectomy. Finally, the use of peroperative algorithm for risk determination could improve patient's staging with a reduction of lymphadenectomy-related morbidity.