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Obstetrics and Gynecology International
Volume 2014, Article ID 278379, 8 pages
Clinical Study

Evaluation of Creatine Kinase, Lactate Dehydrogenase, and Amylase Concentrations in Umbilical Blood of Preterm Infants after Long-Term Tocolysis

Department of Obstetrics and Gynecology, Tokyo Women’s Medical University Yachiyo Medical Center, 477-96 Owadashinden, Chiba, Yachiyo, 276-8524, Japan

Received 20 September 2013; Accepted 31 December 2013; Published 13 February 2014

Academic Editor: Enrique Hernandez

Copyright © 2014 Yoshiyuki Nakajima and Naoki Masaoka. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Creatine kinase (CK), lactate dehydrogenase (LDH), and amylase levels of preterm infants following long-term tocolysis in pregnant women are limited. The objective of this study was to determine if the tocolytic therapy affects CK, LDH, and amylase levels in the umbilical blood. This study included 215 preterm infants born to women treated with and without ritodrine hydrochloride. CK, LDH, and amylase levels in the umbilical blood at delivery were determined. Infants were divided according to the ritodrine tocolysis, as follows: Group A ( ), not exposed to ritodrine; Group B ( ), IV ritodrine for <1 week; Group C ( ), IV ritodrine for ≥1 week. The CK concentration in cord blood of Group C (  IU/L) was significantly higher in comparison with Group A (  IU/L, ). There was no significant difference in LDH and amylase levels in the three groups. The CK significantly correlated with gestational age ( , ) and birth weight ( , ). LDH and amylase levels did not change with gestational age nor birth weight. In conclusion, long-term ritodrine tocolysis leads to increased umbilical blood CK level.