In Women with Previous Pregnancy Hypertension, Levels of Cardiovascular Risk Biomarkers May Be Modulated by Haptoglobin Polymorphism

Table 5

Comparison of blood pressure, anthropometric characteristics, and classic or not biomarkers between women with normal blood pressure in pregnancy (NBPP) and preeclamptic women (PE) according to Haptoglobin phenotype.

	Hp 1.1 plus 2.1			Hp 2.2
	NBPP; 𝑛 (mean ± SD)	PE; 𝑛 (mean ± SD)	𝑃 value	NBPP; 𝑛 (mean ± SD)	PE; 𝑛 (mean ± SD)	𝑃 value
BMI (Kg/m^2)^†	41 (25.18±3.80)	57 (26.95±5.46)	0.061	18 (25.90±4.65)	31 (27.23±3.32)	0.249
WC (cm)^†	38 (82.43±10.0)	57 (90.78±17.58)	0.004	18 (83.47±9.84)	31 (87.26±11.15)	0.238
Systolic BP (mmHg)^†	40 (119.18±13.67)	57 (134.65±18.31)	<0.001	18 (118.22±13.01)	31 (135.61±12.79)	<0.001
Diastolic BP (mmHg)^†	40 (72.80±11.18)	57 (86.19±19.42)	<0.001	18 (70.89±7.15)	31 (85.45±16.26)	<0.001
Pulse pressure^†	40 (46.38±8.12)	57 (48.46±11.89)	0.308	18 (47.33±11.76)	31 (50.16±12.07)	0.429
CRP (mg/L)^††	38 (0.40±0.15)	55 (0.50±0.10)	0.697	18 (0.40±0.12)	28 (0.70±0.09)	0.106
MPO (ng/mL)^†	17 (57.89±32.47)	18 (94.17±42.14)	0.008	7 (72.89±25.64)	14 (74.75±33.89)	0.900
Nitrites (𝜇mol/L)^†	18 (9.57±3.19)	18 (19.98±8.53)	<0.001	7 (11.54±5.06)	14 (18.01±4.44)	0.007
NO𝑥 (𝜇mol/L)^†	18 (79.04±37.15)	17 (101.32±48.79)	0.141	7 (79.53±43.39)	12 (96.79±22.34)	0.356
AST (UI/L)^††	41 (18.00±0.70)	59 (19.00±0.66)	0.084	19 (8.00±1.40)	31 (19.00±1.67)	0.582
ALT (UI/L)^††	41 (15.00±1.13)	59 (18.00±1.04)	0.005	19 (19.00±2.11)	31 (20.00±3.34)	0.234
t-Cholesterol (mg/dL)^†	41 (203.73±33.24)	59 (202.66±38.65)	0.886	19 (212.68±36.63)	31 (215.77±39.81)	0.785
Non HDL cholesterol^†	40 (155.58±35.59)	59 (153.97±37.03)	0.830	19 (160.00±36.41)	31 (166.16±39.03)	0.581
LDL (mg/dL)^†	40 (137.90±33.04)	59 (133.90±33.04)	0.523	19 (140.53±31.49)	31 (146.29±37.61)	0.579
HDL (mg/dL)^†	40 (49.00±1.31)	59 (49.00±1.08)	0.954	19 (56.00±1.95)	31 (49.00±1.59)	0.203
Apo A (mg/dL)^†	41 (0.90±0.17)	58 (0.98±0.16)	0.011	17 (1.07±0.22)	29 (1.02±0.19)	0.405
Apo B (mg/dL)^†	41 (0.58±0.12)	58 (0.62 ± 0.14)	0.122	17 (0.61±0.15)	29 (0.68±0.13)	0.105

†Independent sample 𝑡-test; and values are means ± standard deviation (SD).
††Mann-Whitney 𝑈 test; and values are median ± standard error (SE).
Body mass index (BMI), waist circumference (WC), systolic blood pressure (Systolic BP), diastolic blood (Diastolic BP), pulse pressure, c-reactive protein (CRP), myeloperoxidase (MPO), nitrites, total nitric oxide metabolites (NO_𝑥), aspartate transaminase (AST), alanine transaminase (ALT), total cholesterol (t-cholesterol), non HDL cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), Apolipoprotein A and B (Apo B and Apo A).