Resveratrol, Acetyl-Resveratrol, and Polydatin Exhibit Antigrowth Activity against 3D Cell Aggregates of the SKOV-3 and OVCAR-8 Ovarian Cancer Cell Lines

Figure 7

The secretion of vascular endothelial growth factor (VEGF) of SKOV-3 cell aggregates (a–c) and the morphology of OVCAR-8 3D spheroids (d–r). Higher doses of resveratrol (a), acetyl-resveratrol (b), and polydatin (c) significantly reduced the secretion of VEGF. High concentrations of resveratrol (g and h) and acetyl-resveratrol (l and m) caused the irregular rims of spheroids. Polydatin (q and r) did not show any effect. refers to statistically significant as value less than 0.05 compared to the control.