Table of Contents Author Guidelines Submit a Manuscript
Obstetrics and Gynecology International
Volume 2016 (2016), Article ID 3561675, 7 pages
http://dx.doi.org/10.1155/2016/3561675
Research Article

Large D-Dimer Fluctuation in Normal Pregnancy: A Longitudinal Cohort Study of 4,117 Samples from 714 Healthy Danish Women

Department of Clinical Biochemistry, Copenhagen University Hospital Herlev and Gentofte, 2900 Hellerup, Denmark

Received 1 December 2015; Revised 1 March 2016; Accepted 23 March 2016

Academic Editor: Thomas Herzog

Copyright © 2016 Katrine K. Hedengran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Chang, L. D. Elam-Evans, C. J. Berg et al., “Pregnancy-related mortality surveillance—United States, 1991–1999,” Morbidity and Mortality Weekly Report, vol. 52, no. 2, pp. 1–8, 2003. View at Google Scholar
  2. S. M. Bates, R. Jaeschke, S. M. Stevens et al., “Diagnosis of DVT: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines,” Chest, vol. 141, no. 2, supplement, pp. e351S–e418S, 2012. View at Publisher · View at Google Scholar
  3. G. Bourjeily, M. Paidas, H. Khalil, K. Rosene-Montella, and M. Rodger, “Pulmonary embolism in pregnancy,” The Lancet, vol. 375, no. 9713, pp. 500–512, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. H. James, “Prevention and treatment of venous thromboembolism in pregnancy,” Clinical Obstetrics and Gynecology, vol. 55, no. 3, pp. 774–787, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. P. S. Wells, D. R. Anderson, M. Rodger et al., “Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis,” The New England Journal of Medicine, vol. 349, no. 13, pp. 1227–1235, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Righini, A. Perrier, P. De Moerloose, and H. Bounameaux, “D-Dimer for venous thromboembolism diagnosis: 20 years later,” Journal of Thrombosis and Haemostasis, vol. 6, no. 7, pp. 1059–1071, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. P. B. Szecsi, M. Jørgensen, A. Klajnbard, M. R. Andersen, N. P. Colov, and S. Stender, “Haemostatic reference intervals in pregnancy,” Thrombosis and Haemostasis, vol. 103, no. 4, pp. 718–727, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Kawaguchi, T. Yamada, M. Takeda et al., “Changes in d-dimer levels in pregnant women according to gestational week,” Pregnancy Hypertension, vol. 3, no. 3, pp. 172–177, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Kovac, Z. Mikovic, L. Rakicevic et al., “The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy,” European Journal of Obstetrics Gynecology and Reproductive Biology, vol. 148, no. 1, pp. 27–30, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. J. A. Kline, G. W. Williams, and J. Hernandez-Nino, “D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed,” Clinical Chemistry, vol. 51, no. 5, pp. 825–829, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. Ş. Ercan, S. Özkan, N. Yücel, and A. Orçun, “Establishing reference intervals for D-dimer to trimesters,” Journal of Maternal-Fetal and Neonatal Medicine, vol. 28, no. 8, pp. 983–987, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Murphy, D. I. Broadhurst, A. S. Khashan, O. Gilligan, L. C. Kenny, and K. O'Donoghue, “Gestation-specific D-dimer reference ranges: a cross-sectional study,” BJOG, vol. 122, no. 3, pp. 395–400, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Wang, S. Lu, S. Li, and F. Shen, “Reference intervals of D-dimer during the pregnancy and puerperium period on the STA-R evolution coagulation analyzer,” Clinica Chimica Acta, vol. 425, pp. 176–180, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. C. McLintock, T. Brighton, S. Chunilal et al., “Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period,” Australian and New Zealand Journal of Obstetrics and Gynaecology, vol. 52, no. 1, pp. 14–22, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Henriksson, E. Westerlund, H. Wallén, L. Brandt, O. Hovatta, and A. Ekbom, “Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study,” British Medical Journal, vol. 346, no. 7892, Article ID e8632, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Ricós, V. Alvarez, F. Cava et al., “Current databases on biological variation: pros, cons and progress,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 59, no. 7, pp. 491–500, 1999. View at Publisher · View at Google Scholar
  17. A. Klajnbard, P. B. Szecsi, N. P. Colov et al., “Laboratory reference intervals during pregnancy, delivery and the early postpartum period,” Clinical Chemistry and Laboratory Medicine, vol. 48, no. 2, pp. 237–248, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. P. B. Szecsi, M. R. Andersen, B. Bjørngaard, K. K. Hedengran, and S. Stender, “Cancer antigen 125 after delivery in women with a normal pregnancy: a prospective cohort study,” Acta Obstetricia et Gynecologica Scandinavica, vol. 93, no. 12, pp. 1295–1301, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Hammerova, J. Chabada, J. Drobny, and A. Batorova, “Longitudinal evaluation of markers of hemostasis in pregnancy,” Bratislavské Lekárske Listy, vol. 115, no. 3, pp. 140–144, 2014. View at Google Scholar
  20. M. A. Medow and C. R. Lucey, “A qualitative approach to Bayes' theorem,” Evidence-Based Medicine, vol. 16, no. 6, pp. 163–167, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Epiney, F. Boehlen, M. Boulvain et al., “D-dimer levels during delivery and the postpartum,” Journal of Thrombosis and Haemostasis, vol. 3, no. 2, pp. 268–271, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Johna, S. Cemaj, T. O'Callaghan, and R. Catalano, “Effect of tissue injury on D-Dimer levels: a prospective study in trauma patients,” Medical Science Monitor, vol. 8, no. 1, pp. CR5–CR8, 2002. View at Google Scholar · View at Scopus
  23. A. N. Leung, T. M. Bull, R. Jaeschke et al., “An official American Thoracic Society/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy,” American Journal of Respiratory and Critical Care Medicine, vol. 184, no. 10, pp. 1200–1208, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Conti, L. Zezza, E. Ralli et al., “Pulmonary embolism in pregnancy,” Journal of Thrombosis and Thrombolysis, vol. 37, no. 3, pp. 251–270, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Sivandarajah, “Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 4: current evidence does not support the use of a negative D-dimer to rule out suspected pulmonary embolism in pregnancy,” Emergency Medicine Journal, vol. 28, no. 3, pp. 245–246, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Middeldorp, “Thrombosis in women: what are the knowledge gaps in 2013?” Journal of Thrombosis and Haemostasis, vol. 11, supplement 1, pp. 180–191, 2013. View at Publisher · View at Google Scholar · View at Scopus