|
| Registry | Pregnancies exposed (maternal exp.) | Disease | Anti-TNF agent administered | Results |
|
| Katz et al. 2004 [17] | 131 (96 available data) | CD, UC, RA | INF (96 patients) | Live births 64
Miscarriages 14
Theur. Term. 18 |
|
Chambers et al. 2004 [18]
OTIS | 33 | RA, CD | INF (4 patients)
ETA (29 patients) | Live births ETA: 7 IFX: 2
Miscarriages ETA: 3 IFX: 1
Theur. Term. ETA: 1 IFX: 1
Trisomy 18 ETA: 1 |
|
| Mahadevan et al. 2005 [19] | 10 | CD | INF (10 patients) | Live births 10
Premature births 3
Low birth weight 1 |
|
| Joven et al. 2005 [20] | 14 | RA, PsA, JIA | INF (4 patients)
ETA (8 patients)
ADA (2 patients) | Live births 7
Miscarriages 1
Theur. Term. 4
On-going pregnancies 2 |
|
Strangfeld et al. 2007 [21]
RABBIT | 37 | RA | INF (2 patients)
ETA (20 patients)
ADA (5 patients) | No relation between the use of anti TNF agents prior to conception and miscarriages, higher congenital malformations, or low birth weight (4.5% versus 6.6%) |
|
Verstappen et al. 2011 [22]
BSRBR | 130 | RA, PsA, JIA, AS, SLE, AOSD | INF (30 patients)
ETA (73 patients)
ADA (26 patients) | Live births 88
Theur. Term. 10
Spontaneous abortion was highest among patients exposed to anti-TNF at the time of conception (17% versus 10%) |
|
| Schnitzler et al. 2011 [23] | 42 | IBD | INF (35 patients)
ADA (7 patients) | Live births 32
Low birth weight 6
Premature births 3
On-going pregnancies 1 |
|
| Clowse et al. 2015 [25] | 339 | RA, CD | CZP (339 patients) | Live births 254
Miscarriages 52
Induced abortion 32
Stillbirth 1 |
|
| Hoxha et al. 2016 [26] | 35 | RA, PsA,
AS | INF (3 patients)
ETA (25 patients)
ADA (5 patients)
CZP (2 patients) | Live births 31
Spontaneous abortion 4
Premature birth 2
Trisomy 16 1
Congenital diaphragmatic hernia and obstructive megaureter 1 |
|
| Komoto et al. 2016 [27] | 34 | IBD | INF (33 patients)
ADA (1 patient) | Live births 34
Spontaneous abortion 6
Premature birth 2
Low birth weight 6
Congenital anomaly 1 |
|
