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Obstetrics and Gynecology International
Volume 2016 (2016), Article ID 8790120, 5 pages
http://dx.doi.org/10.1155/2016/8790120
Research Article

Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix

1Department of Pathology, College of Medicine, Omdurman Islamic University, 382 Omdurman, Sudan
2Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 6666, Saudi Arabia
3Department of Histopathology and Cytology, College of Medical Laboratories Science, University of Sciences and Technology, Omdurman, Sudan
4College of Veterinary Medicine, Suez Canal University, Ismailia, Egypt

Received 11 November 2015; Revised 19 January 2016; Accepted 14 February 2016

Academic Editor: W. T. Creasman

Copyright © 2016 Nazik Elmalaika O. S. Husain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cervical cancer is one of the commonest types of cancers worldwide especially in developing countries. Intermediate filaments protein family has shown a role in the diagnosis of various cancers, but a few studies are available about the vimentin and cytokeratin roles in the cervical cancer. This case control study aimed to interpret the expression of vimentin and cytokeratin proteins in the development and progression of cervical cancer and its correlation with clinicopathological features. The cytoplasmic expression of vimentin was observed in 40% of cases, but not in inflammatory lesions of cervix. It was noticed that vimentin expression was increasing significantly with high grade of the tumour. Cytokeratin expression was observed in 48.33% and it was noticed that the expression was 62.5% in well differentiated (G1), 45% in moderately differentiated (G2), and 41.66% in poorly differentiated carcinoma, yet statistically insignificant. The expression of vimentin and cytokeratin proteins was not significantly associated with age groups. The current findings concluded a possible role of vimentin in the development and progression of cervical cancer and vimentin marker will be useful in the diagnosis and grading of cervical cancer.