Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage

Table 19

Analysis of the individual effects of TLR2, TLR4, TLR9, TNFα, PGR, IL-6, IL-8, IL-10, and TGF-β1 genotypes on the risk of miscarriage with multiple logistic regression.

	Estimate	Std. error	z value	Pr (>|z|)
(Intercept)	1.93624	0.67065	−2.887	0.003888
TLR2 GA	4.91960	1.62537	3.027	0.002472
TLR4 CT	1.07696	0.71345	1.510	0.131167
TLR9 AA	3.25877	0.77968	4.180	2.92e−05
TLR9 GA	2.22891	0.53278	4.184	2.87e−05
PGR T1T2	−0.79836	0.54428	−1.467	0.142428
PGR T2T2	−0.14348	1.43022	−0.100	0.920088
TGF-β1 CT	−0.61884	0.44058	−1.405	0.160142
TGF-β1 TT	−0.78374	0.85355	−0.918	0.358509
IL-6 CC	−2.23917	0.78448	−2.854	0.004313
IL-6 GC	0.18254	0.47991	0.380	0.703677
IL-8 CT	1.65668	0.57878	2.862	0.004205
IL-8 TT	0.85917	0.62898	1.366	0.171950
IL-10 AA	16.43724	1354.17780	0.012	0.990315
IL-10 CA	1.91552	0.53608	3.573	0.000353
TNF GA	−0.05164	0.49134	−0.105	0.916304

Significance codes: 0 ‘’ 0.001 ‘’ 0.01 ‘’ 0.05 ‘.’ 0.1 ‘ ’ 1.