Effects of Single-Nucleotide Polymorphisms in Cytokine, Toll-Like Receptor, and Progesterone Receptor Genes on Risk of Miscarriage

Table 25

Major double genetic interactions that affect the risk of miscarriage.

Increasing risk of miscarriage	Decreasing risk of miscarriage
TLR9 GA + IL-6 CC	TLR9 GG + IL-6 GG
TLR9 GA + IL-6 GC	TLR9 GG + IL-6 GC
TLR9 GA + IL-8 CT	TLR9 GG + IL-8 TT
TLR9 GA + IL-8 TT	TLR9 GG + IL-8 CT
TLR9 AA + IL-8 CT	TLR9 GA + IL-8 CC
TLR9 AA + IL-8 TT	TLR9 GG + IL-8 CC
TLR9 GA + IL-10 AA	TLR9 GG + IL-10 CC
TLR9 GA + IL-10 CA	TLR9 GG + IL-10 CA
TLR9 AA + IL-10 AA
TLR9 AA + IL-10 CA
IL-10 AA + TLR4 CC
IL-10 CA + TLR4 CT