Table of Contents Author Guidelines Submit a Manuscript
Obstetrics and Gynecology International
Volume 2018, Article ID 9628726, 12 pages
https://doi.org/10.1155/2018/9628726
Research Article

Are There Differences in the Anthropometric, Hemodynamic, Hematologic, and Biochemical Profiles between Late- and Early-Onset Preeclampsia?

1Faculty of Medicine, Federal University of Uberlândia, Uberlândia, MG, Brazil
2Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, MG, Brazil

Correspondence should be addressed to Nilson Penha-Silva; rb.ufu@ahnepsn

Received 29 August 2017; Revised 13 November 2017; Accepted 4 January 2018; Published 1 March 2018

Academic Editor: Curt W. Burger

Copyright © 2018 Márcia Aires Rodrigues de Freitas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Preeclampsia (PE) is classified as early-onset PE (EOPE) and late-onset PE (LOPE) when present before or after 34 weeks of gestation, respectively. This transversal study aimed to investigate the differences and possible associations existing in the anthropometric, hemodynamic, hematologic, and biochemical profiles of late- and early-onset preeclampsia. The study included 65 volunteers admitted to a tertiary hospital in Brazil: 29 normotensive and 36 with preeclampsia (13 with EOPE and 23 with LOPE). Pregnant women with LOPE presented greater weight gain and borderline increase in body mass index at the end of gestation in relation to the other groups, which is compatible with the metabolic origin, associated with obesity, attributed to this form of the disease. Pregnant women with EOPE presented a borderline reduction in the number of erythrocytes and a significant decrease in the number of platelets, in addition to a significant increase in reticulocytes, serum iron, and ferritin when compared to normotensive pregnant women and pregnant women with LOPE. A significant increase in osmotic stability of erythrocytes was observed in the EOPE group in relation to other groups. Hemodynamic analysis by Doppler ultrasonography of the ophthalmic artery showed that both groups of pregnant women with PE presented alterations compatible with the occurrence of hyperflow in the orbital territory. These hemodynamic changes were associated with changes in hematimetric indices.