Research Article
Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol
Table 1
Patients’ clinical characteristics (
).
| | Characteristics | (%) |
| | Age distribution | | | Median age | 53 | | Age < 45 | 3 (16.7) | | Age ranges from 45 to 60 | 12 (66.7) | | Age ≥ 60 | 3 (16.7） | | Clinical symptoms | | | Irregular vaginal bleeding | 12 (66.7) | | Contact vaginal bleeding | 2 (11.1) | | Abnormal vaginal discharge | 3 (16.7) | | Unknown | 1 | | Childbearing history | | | Nulliparous | 2 (11.1) | | Parous | 16 (83.3) | | Menopausal status | | | Premenopausal | 6 (33.3) | | Postmenopausal | 11 (61.1) | | Cervical stump | 1 (5.6) | | Macropathology | | | Endocervical type | 12 (66.7) | | Exogenic type | 2 (11.1) | | Endogen type | 2 (11.1) | | Ulcer type | 1 (5.6) | | Unknown | 1 (5.6) | | Tumor size (cm) | | | ≤4 cm | 5 (27.8) | | >4 cm | 11 (61.1) | | Unknown | 2 (11.1) | | HPV-DNA () | | | Positive | 1 (11.1) | | Negative | 8 (88.9) | | TCT () | | | Positive | 4 (66.7) | | Negative | 2 (33.3) | | FIGO stage | | | I | 10 (55.6) | | II | 3 (16.7) | | III | 4 (22.2) | | IV | 1 (5.6) | | FIGO stage | | | IB1-IIA1 | 11 (61.1) | | IIA2-IV | 7 (38.9) | | Neoadjuvant chemotherapy | | | Yes | 2 (11.1) | | No | 16 (88.9) | | Surgery | | | Yes | 17 (94.4) | | No | 1 (5.6) | | Extent of surgery () | | | RAH + BSO + PL | 13 (76.5) | | RAH + BSO + PL + PAL | 2 (11.8) | | EH + BSO | 1 (5.8) | | RECS | 1 (5.8) | | Cervical invasion () | | | <1/3 | 6 (35.3) | | Full-thickness | 11 (64.7) | | LVSI | | | Yes | 1 (5.8) | | No | 16 (94.1) | | PLN metastasis () | | | Yes | 4 (26.7) | | No | 11 (73.3) | | Endometrial/uterine corpus metastasis () | | | Yes | 4 (25) | | No | 12 (75) | | Ovarian metastasis () | | | Yes | 1 (6.7) | | No | 14 (93.3) | | Adjuvant treatment () | | | PPBC | 4 (36.4) | | PR | 1 (9.1) | | PPBC + PR | 4 (36.4) | | NC + PR | 2 (18.2) |
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BSO, bilateral salpingo-oophorectomy; RAH, radical abdominal hysterectomy; PL, pelvic lymphadenectomy; PAL, paraaortic lymphadenectomy; EH, extrafascial hysterectomy; RECS: radical excision of cervical stump; PPBC: postoperative platinum-based chemotherapy.
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