Meta-Analysis of VTE Risk: Ovarian Cancer Patients by Stage, Histology, Cytoreduction, and Ascites at Diagnosis

Table 1

Description of the included studies.

Author, year	Study type	N VTE/N total	Location of study	Timing of study	Pharmacologic anticoagulation	Timing of VTE	Outcome	Diagnosis
Bakhru, 2012	Retrospective cohort	69/641	Michigan, USA; University of Michigan Medical Center	1999–2009	Unknown	Postoperative	DVT	Symptomatic evaluation
Black, 2007	Retrospective cohort	57/559	New York, USA; Gynecologic Service Database of Memorial Sloan-Kettering Cancer Center	01/1999–04/2015	Heparin given at surgeon’s discretion	Diagnosis to 30 days Postoperative	PE, DVT	Symptomatic evaluation
Duska, 2009	Retrospective cohort	37/129	Massachusetts, USA; Massachusetts General Hospital	1994–2004	All patients received pre- and postoperative subcutaneous heparin	Over the clinical course of disease until death, loss to follow-up, or 2004	PE, DVT	Symptomatic evaluation
Ebina, 2018	Prospective cohort	25/110	Kobe, Japan; Kobe University Hospital	6/2010–12/2016	Unknown	Prior to the start of any treatment	DVT, DVT, and PE	Screening with ultrasound and CT scan
Fotopoulou, 2009	Retrospective cohort	37/525	Germany; two clinical trials of the North-Eastern German Society of Gynecologic Oncology Ovarian Cancer Study Group	09/1999–08/2005	Prophylactic care to patient’s physician preference	During 2^nd line topotecan-based chemotherapy	VTE	Symptomatic evaluation
Gunderson, 2014	Retrospective cohort	94/586	Oklahoma, USA; University of Oklahoma Health Sciences Center	01/1996–06/2011	Unknown	At diagnosis through last follow-up	PE, DVT	Symptomatic evaluation
Heath, 2015	Retrospective cohort	19/397	London, UK; Royal Marsden Hospital and St. George’s Hospital	01/2006–12/2012	Unknown	Pre- and postoperative	PE, DVT	Screening and symptomatic evaluation
Kawaguchi, 2012	Retrospective cohort	14/87	Nara, Japan; Shizuokas Cancer Center Hospital	07/2007–10/2008	Unknown	preoperative and pretreatment	DVT, DVT, and PE	Screening using ultrasound and CT scan
Kodama, 2012	Retrospective cohort	23/114	Okayama, Japan; Okayama University Hospital	08/2005–08/2011	Unknown	preoperative	VTE	High D-dimer and clinically symptomatic evaluation
Mereu, 2009	Retrospective cohort	16/203	Pavia, Italy; San Matteo Hospital	1990–2004	Surgical patients received heparin for 7 days after surgery	During chemotherapy treatment	PE, DVT	Evaluated on clinical suspicion of disease
Mokri, 2013	Retrospective cohort	35/569	Minnesota, USA; Mayo Clinic Hospital	01/2003–12/2008	To surgeon’s preference	Postoperative	PE, DVT	Symptomatic evaluation
Saadeh, 2013	Retrospective cohort	33/344	Dublin, Ireland; St. Jame Hospital	2006–2010	Surgical patients received heparin	Diagnosis to 8 months, variable treatments received in time frame	PE, DVT	Routine staging CT and symptomatic evaluation
Sakurai, 2017	Prospective cohort	31/128	Tsukuba, Japan; University of Tsukuba Hospital	11/2004–12/2010	Unknown	Postoperative	DVT, DVT, and PE	Screening with ultrasound, CT and MRI
Satoh, 2007	Prospective cohort	18/72	Tsukuba, Japan; University of Tsukuba Hospital	11/2004–03/2007	Unknown	Prior to treatment and surgery	DVT, PE	Screening with ultrasound, CT and MRI
Suzuki, 2010	Retrospective cohort	21/144	Kanagawa, Japan; St. Marianna University School of Medicine Department of Obstetrics and Gynecology	01/2005–06/2008	Some patients received presurgery anticoagulation	Preoperative	DVT, PE	Screening CT and ultrasound in patients with high D-dimer levels before surgery
Tateo, 2005	Retrospective cohort	42/253	Pavia, Italy; San Matteo Hospital	1990–2001	Heparin for at least 7 days after surgery	Diagnosis until follow-up; average follow-up or time even was 24.3 months	DVT, PE	Symptomatic evaluation on clinical suspicion
Uno, 2007	Prospective cohort	10/32	Tsukuba, Japan; University of Tsukuba Hospital	01/2004	Unknown	preoperative	DVT, DVT, and PE	Screening with ultrasound, CT and MRI
Wagner, 2014	Retrospective cohort	140/860	Minnesota, USA; Mayo Clinic Hospital	01/2003–12/2011	To surgeon’s preference	6 months after primary debulking surgery	DVT, PE	Symptomatic evaluation; self-report; next-of-kin report; autopsy
Wu, 2013	Retrospective cohort	13/183	Shanghai, China; Fudan University Cancer Hospital	07/2007–01/2011	Unknown	Diagnosis to at least 5 months postoperative	DVT, PE	Self-report by telephone and outpatient chart review (symptomatic evaluation)
Zhang, 2018	Retrospective cohort	35/388	Shandong, China; Qilu Hospital of Shandong University	01/2014–01/2017	Preoperative VTE cases were given heparin, 7 days of heparin given after surgery	Diagnosis to last chemotherapy treatment (>6 months)	DVT, PE	Preoperative screening with ultrasound and symptomatic evaluation after surgery

This table details the studies included in this meta-analysis. This table details the risk of bias by manuscript according to the Newcastle–Ottawa cohort study assessment tool. Two stars (or points) were possible in the “on basis of design” category, whereas only one point (or star) was possible in the other categories.