Placenta Creta: A Spectrum of Lesions Associated with Shallow Placental Implantation

Figure 2

Lesions of shallow placental implantation (a–c), hypoxic lesions (d–f), and fetal vascular malperfusion lesions (g, h) statistically significant more common in group 1 (original objective magnifications are given in parentheses). (a) Confluent cell islands (excessive extravillous trophoblasts) (haematoxylin eosin, 4x). (b) Chorionic microcysts (haematoxylin eosin, 4x). (c) A cluster of multinucleate trophoblasts and hypertrophic decidual arteriopathy in maternal floor (haematoxylin eosin, 40x). (d) Uterine chronic hypoxic pattern at 34 weeks gestation (haematoxylin eosin, 10x). (e) Villous infarction (haematoxylin eosin, 10x). (f) Massive perivillous fibrinoid deposition (dissecting microscopy). (g) Incipient segmental villous hypovascularity (E cadherin (brown)/CD34 (red) immunostain, 10x). (h) Fetal stem vascular ectasia, global fetal vascular malperfusion (haematoxylin and eosin, 4x).