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Oxidative Medicine and Cellular Longevity
Volume 1 (2008), Issue 1, Pages 1-14
http://dx.doi.org/10.4161/oxim.1.1.6842

Therapeutic Promise and Principles: Metabotropic Glutamate Receptors

1Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, MI, USA
2Departments of Neurology and Anatomy & Cell Biology, Wayne State University School of Medicine, Detroit, MI, USA
3Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
4Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA
5Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA

Received 21 August 2008; Revised 26 August 2008; Accepted 27 August 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

For a number of disease entities, oxidative stress becomes a significant factor in the etiology and progression of cell dysfunction and injury. Therapeutic strategies that can identify novel signal transduction pathways to ameliorate the toxic effects of oxidative stress may lead to new avenues of treatment for a spectrum of disorders that include diabetes, Alzheimer's disease, Parkinson's disease and immune system dysfunction. In this respect, metabotropic glutamate receptors (mGluRs) may offer exciting prospects for several disorders since these receptors can limit or prevent apoptotic cell injury as well as impact upon cellular development and function. Yet the role of mGluRs is complex in nature and may require specific mGluR modulation for a particular disease entity to maximize clinical efficacy and limit potential disability. Here we discuss the potential clinical translation of mGluRs and highlight the role of novel signal transduction pathways in the metabotropic glutamate system that may be vital for the clinical utility of mGluRs.