Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity / 2010 / Article

Open Access

Volume 3 |Article ID 593214 | https://doi.org/10.4161/oxim.3.3.12106

Eric E. Essick, Flora Sam, "Oxidative Stress and Autophagy in Cardiac Disease, Neurological Disorders, Aging and Cancer", Oxidative Medicine and Cellular Longevity, vol. 3, Article ID 593214, 10 pages, 2010. https://doi.org/10.4161/oxim.3.3.12106

Oxidative Stress and Autophagy in Cardiac Disease, Neurological Disorders, Aging and Cancer

Received04 Apr 2010
Revised18 Apr 2010
Accepted19 Apr 2010

Abstract

Autophagy is a catalytic process of the bulk degradation of long-lived cellular components, ultimately resulting in lysosomal digestion within mature cytoplasmic compartments known as autophagolysosomes. Autophagy serves many functions in the cell, including maintaining cellular homeostasis, a means of cell survival during stress (e.g., nutrient deprivation or starvation) or conversely as a mechanism for cell death. Increased reactive oxygen species (ROS) production and the resulting oxidative cell stress that occurs in many disease states has been shown to induce autophagy. The following review focuses on the roles that autophagy plays in response to the ROS generated in several diseases.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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