Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity / 2010 / Article

Open Access

Volume 3 |Article ID 735923 | https://doi.org/10.4161/oxim.3.5.13109

Gislaine Z. Réus, Roberto B. Stringari, Bruna de Souza, Fabrícia Petronilho, Felipe Dal-Pizzol, Jaime E. Hallak, Antônio W. Zuardi, José A. Crippa, João Quevedo, "Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus", Oxidative Medicine and Cellular Longevity, vol. 3, Article ID 735923, 7 pages, 2010. https://doi.org/10.4161/oxim.3.5.13109

Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus

Received15 Jul 2010
Revised20 Jul 2010
Accepted21 Jul 2010

Abstract

A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the effects of acute and chronic administration of harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) or saline in lipid and protein oxidation levels and superoxide dismutase (SOD) and catalase (CAT) activities in rat prefrontal cortex and hippocampus. Acute and chronic treatments with imipramine and harmine reduced lipid and protein oxidation, compared to control group in prefrontal cortex and hippocampus. The SOD and CAT activities increased with acute and chronic treatments with imipramine and harmine, compared to control group in prefrontal cortex and hippocampus. In conclusion, our results indicate positive effects of imipramine antidepressant and β-carboline harmine of oxidative stress parameters, increasing SOD and CAT activities and decreasing lipid and protein oxidation.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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