Table 3: Effect of feeding different combinations on hepatic lipid profiles, HMG-CoA reductase activity and bile acid content (mg/gm).

GroupNCHCC-IC-IIC-III

Total lipids30 ± 2.9d126.8 ± 4.3a (+322.76)91.7 ± 3.1bc (−27.72)83.8 ± 3.2c (−33.90)101.3 ± 3.1b (−20.10)
Total cholesterol1.9 ± 0.1d36.1 ± 1.7a (+1769.43)24.9 ± 1.5bc (−30.90)23.5 ± 1.3bc (−34.75)29 ± 1.4b (−19.53)
Triglycerides3 ± 0.1b24.3 ± 1.4a (+705.96)20.2 ± 1.2a (−17.00)22.1 ± 1.7a (−9.20)22.3 ± 1.8a (−8.50)
HMG CoA reductase*2.8 ± 0.1e7.1 ± 0.1a (−156.67)6 ± 0.1bc (+15.75)5.8 ± 0.1cd (+18.84)6.2 ± 0.1b (+12.93)
Bile acid3.8 ± 0.1d6.9 ± 0.1c (+83.55)8.8 ± 0.1a (+27.45)9.2 ± 0.1a (+33.09)8 ± 0.1b (+16.18)

Values: mean ± SEM (n = 6).
Figures in parentheses indicate percent increase (+) or decrease (−).
Within a row those with different superscripts are significantly different (P < 0.002).
*HMG-CoA reductase activity is inversely proportional to the ratio of HMG-CoA/mevalonate (absorbance of HMG-CoA/absorbance of mevalonate), that is, the increase in ratio corresponds to a decrease in enzyme activity.
Comparisons for the percentage were made between groups NC and HC; HC and C-I; HC and C-II; HC and C-III.