Acetaldehyde-Mediated Neurotoxicity: Relevance to Fetal Alcohol Spectrum Disorders
Figure 5
Effects of prenatal ethanol exposure on expression of alcohol metabolizing enzyme gene expression in cerebellar tissue. Cerebella from postnatal day 2-3 rat pups from dams that had been chronically fed with isocaloric liquid diets containing 0%, 18%, or 37% ethanol by caloric content were used to measure expression of different isoforms of (a) alcohol dehydrogenase (ADH) or (b) aldehyde dehydrogenase (ALDH), as well as catalase and CYP2E1 by qRT-PCR analysis. Results were normalized to 18S rRNA measured in the same samples. Inter-group comparisons were made using repeated measures ANOVA with the Dunnett post hoc test to detect significant differences from control. *; ***.
