4-Hydroxy-2-Nonenal-Modified Glyceraldehyde-3-Phosphate Dehydrogenase Is Degraded by Cathepsin G in Rat Neutrophils

Figure 6

Mechanisms responsible for removing proteins modified by lipid peroxidation products. The major proteolytic system for the degradation of oxidized or HNE-modified proteins is the ubiquitin-proteasome pathway. Ubiquitin-dependent lysosomal degradation of HNE-modified proteins also has been reported in human lens epithelial cells. We observed that HNE-modified GAPDH was degraded by cathepsin G in granulocytes and monocytes.