Oxidative Medicine and Cellular Longevity / 2011 / Article / Tab 4

Research Article

Evaluation of Chromosomal Instability in Diabetic Rats Treated with Naringin

Table 4

Frequencies of sperm count, abnormalities, ROS, GSSG, GSH, GSSG/GSH ratio, and MDA of nondiabetic and diabetic rats 24 hours after the last treatment with the indicated doses of naringin (4 weeks exposures, spaced 24 hours apart) (mean ± SD).

Treatment groups (mg/kg)Counts (×106/couda epididymis)Abnormal sperm (%)MDA (nmol/mg protein)GSH ( g/mg protein)GSSG ( g/mg protein)GSH/GSSG ratioROS (% of control)

Nondiabetic control46.8 ± 6.72.2 ± 0.812.6 ± 1.81.8 ± 0.40.26 ± 0.057.4 ± 2.5100.0 ± 7.4
Nondiabetic + naringin (25)49.0 ± 5.71.8 ± 0.811.4 ± 3.21.9 ± 0.40.24 ± 0.058.1 ± 2.095.4 ± 8.5
Nondiabetic + naringin (50)51.0 ± 7.31.6 ± 0.5410.4 ± 2.72.2 ± 0.50.25 ± 0.078.3 ± 2.893.2 ± 9.3
Diabetes34.8 ± 3.3*6.4 ± 1.3*19.6 ± 3.7*0.8 ± 0.2*0.36 ± 0.04*2.4 ± 0.8160.8 ± 15.5*
Diabetes + naringin (25) a a b b a b b
Diabetes + naringin (50) b b b b b b b

* versus nondiabetic control (Kruskal-Wallis test followed by Dunn’s multiple comparisons test), a , b versus diabetes alone (Mann-Whitney U test). MDA: malondialdehyde; GSH: reduced glutathione; GSSG: oxidized glutathione; ROS: reactive oxygen species.

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