Reversible Oxidation of Myometrial Voltage-Gated Potassium Channels with Hydrogen Peroxide
Figure 2
Time-dependent changes in effect of H2O2 (400 μM and 3 mM) in spontaneous (a) and Ca2+-induced, (b) rat uteri contractile activity in the presence of channel inhibitor, 4-AP 1 mM. Contractile activity is expressed as change in contraction amplitude (%) after applying H2O2. Full line represents amplitude changes on every 15 min and dotted line on every 5 min after applying H2O2 (400 μM and 3 mM). 3 mM H2O2 had prolonged effect (time for contractions to equilibrate: 30 min). Values are expressed as mean ± error. -axis represents the full experiment time starting from 30 min, which is the uteri equilibration interval.
