Intensification of Doxorubicin-Related Oxidative Stress in the Heart by Hypothyroidism Is Not Related to the Expression of Cytochrome P450 NADPH-Reductase and Inducible Nitric Oxide Synthase, As Well As Activity of Xanthine Oxidase
Table 6
Xanthine oxidase activity (μU/g of cardiac sample; .) in rat cardiac homogenates 4, 48, and 96 h after doxorubicin administration.
Time from DOX injection (h)
Dose of DOX (mg/kg b.w.)
Methimazole
ANOVA
0.0000
0.001%
0.025%
4
2
0.6229
5
0.9680
15
*,#
#,†
0.0171
48
2
0.1998
5
0.0602
15
0.9324
96
2
0.3705
5
0.3724
15
0.6057
0.9% NaCl
(control)
* versus control; #DOX + MET versus DOX; †DOX + METH versus DOX + METL.