Table of Contents Author Guidelines Submit a Manuscript
Oxidative Medicine and Cellular Longevity
Volume 2012, Article ID 165127, 6 pages
http://dx.doi.org/10.1155/2012/165127
Research Article

Antioxidant Capacity of Flavonoids in Hepatic Microsomes Is not Reflected by Antioxidant Effects In Vivo

Natural Products Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK

Received 13 April 2012; Revised 6 June 2012; Accepted 8 June 2012

Academic Editor: Mohammad Abdollahi

Copyright © 2012 Garry Duthie and Philip Morrice. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. B. McPhail, R. C. Hartley, P. T. Gardner, and G. G. Duthie, “Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy,” Journal of Agricultural and Food Chemistry, vol. 51, no. 6, pp. 1684–1690, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. P. G. Pietta, “Flavonoids as antioxidants,” Journal of Natural Products, vol. 63, no. 7, pp. 1035–1042, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. O. I. Aruoma, “Free radicals, oxidative stress, and antioxidants in human health and disease,” Journal of the American Oil Chemists' Society, vol. 75, no. 2, pp. 199–212, 1998. View at Google Scholar · View at Scopus
  4. G. G. Duthie, “Determination of activity of antioxidants in human subjects,” Proceedings of the Nutrition Society, vol. 58, no. 4, pp. 1015–1024, 1999. View at Google Scholar · View at Scopus
  5. P. C. H. Hollman, A. Cassidy, B. Comte et al., “The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established,” Journal of Nutrition, vol. 141, no. 5, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Kyle and G. G. Duthie, “Nutritional relevance of flavonoids in disease prevention,” Natural Products Communications, no. 11, pp. 1049–1060, 12006. View at Google Scholar
  7. W. Wiczkowski, J. Romaszko, A. Bucinski et al., “Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides,” Journal of Nutrition, vol. 138, no. 5, pp. 885–888, 2008. View at Google Scholar · View at Scopus
  8. J. H. Mitchell, P. T. Gardner, D. B. McPhail, P. C. Morrice, A. R. Collins, and G. G. Duthie, “Antioxidant efficacy of phytoestrogens in chemical and biological model systems,” Archives of Biochemistry and Biophysics, vol. 360, no. 1, pp. 142–148, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Ramirez-Tortosa, Ø. M. Andersen, P. T. Gardner et al., “Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats,” Free Radical Biology and Medicine, vol. 31, no. 9, pp. 1033–1037, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. S. J. Duthie, P. T. Gardner, P. C. Morrice et al., “DNA stability and lipid peroxidation in vitamin E-deficient rats in vivo and colon cells in vitro: modulation by the dietary anthocyanin, cyanidin-3-glycoside,” European Journal of Nutrition, vol. 44, no. 4, pp. 195–203, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. J. A. M. Kyle and G. G. Duthie, “Flavonoids in foods,” in Flavonoids: Chemistry, Biochemistry and Applications, M. Ø. Andersen and K. R. Markam, Eds., p. 219, Taylor and Francis Group, Boca Raton, Fla, USA, 2006. View at Google Scholar
  12. P. C. Morrice, S. G. Wood, and G. G. Duthie, “High-performance liquid chromatographic determination of quercetin and isorhamnetin in rat tissues using β-glucuronidase and acid hydrolysis,” Journal of Chromatography B, vol. 738, no. 2, pp. 413–417, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. J. A. M. Kyle, P. C. Morrice, G. McNeill, and G. G. Duthie, “Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea,” Journal of Agricultural and Food Chemistry, vol. 55, no. 12, pp. 4889–4894, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. G. G. Duthie, J. R. Arthur, P. Bremner, Y. Kikuchi, and F. Nicol, “Increased peroxidation of erythrocytes of stress-susceptible pigs: an improved diagnostic test for porcine stress syndrome,” American Journal of Veterinary Research, vol. 50, no. 1, pp. 84–87, 1989. View at Google Scholar · View at Scopus
  15. G. D. Duthie, D. B. McPhail, J. R. Arthur, B. A. Goodman, and P. C. Morrice, “Spin trapping of free radicals and lipid peroxidation in microsomal preparations from malignant hyperthermia susceptible pigs,” Free Radical Research Communications, vol. 8, no. 2, pp. 93–99, 1990. View at Google Scholar · View at Scopus
  16. C. K. Chow, “Increased activity of pyruvate kinase in plasma of vitamin E deficient rats,” Journal of Nutrition, vol. 105, no. 9, pp. 1221–1224, 1975. View at Google Scholar · View at Scopus
  17. K. L. Khanduja and A. Bhardwaj, “Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids,” Indian Journal of Biochemistry and Biophysics, vol. 40, no. 6, pp. 416–422, 2003. View at Google Scholar · View at Scopus
  18. C. J. Bennett, S. T. Caldwell, D. B. McPhail, P. C. Morrice, G. G. Duthie, and R. C. Hartley, “Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation,” Bioorganic and Medicinal Chemistry, vol. 12, no. 9, pp. 2079–2098, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. V. Crespy, C. Morand, C. Besson, C. Manach, C. Demigne, and C. Remesy, “Quercetin, but not its glycosides, is absorbed from the rat stomach,” Journal of Agricultural and Food Chemistry, vol. 50, no. 3, pp. 618–621, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. P. C. H. Hollman, M. N. C. P. Bijsman, Y. Van Gameren, E. P. J. Cnossen, J. H. M. De Vries, and M. B. Katan, “The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man,” Free Radical Research, vol. 31, no. 6, pp. 569–573, 1999. View at Google Scholar · View at Scopus
  21. C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Rémésy, “Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies,” The American journal of clinical nutrition, vol. 81, no. 1, 2005. View at Google Scholar · View at Scopus
  22. Y. Nakamura, S. Ishimitsu, and Y. Tonogai, “Effects of quercetin and rutin on serum and hepatic lipid concentrations, fecal steroid excretion and serum antioxidant properties,” Journal of Health Science, vol. 46, no. 4, pp. 229–240, 2000. View at Google Scholar · View at Scopus
  23. H. Wiegand, C. Boesch-Saadatmandi, S. Wein, S. Wolffram, J. Frank, and G. Rimbach, “Dietary flavonoids do not affect vitamin E status in growing rats,” Journal of Animal Physiology and Animal Nutrition, vol. 94, no. 3, pp. 307–318, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Augustin, R. Blank, C. Boesch-Saadatmandi, J. Frank, S. Wolffram, and G. Rimbach, “Dietary green tea polyphenols do not affect vitamin E status, antioxidant capacity and meat quality of growing pigs,” Journal of Animal Physiology and Animal Nutrition, vol. 92, no. 6, pp. 705–711, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Frank, T. W. George, J. K. Lodge et al., “Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men,” Journal of Nutrition, vol. 139, no. 1, pp. 58–62, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Masella, R. Di Benedetto, R. Varì, C. Filesi, and C. Giovannini, “Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes,” Journal of Nutritional Biochemistry, vol. 16, no. 10, pp. 577–586, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Hasani-Ranjbar, B. Larijani, and M. Abdollahi, “A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases,” Inflammation and Allergy, vol. 8, no. 1, pp. 2–10, 2009. View at Publisher · View at Google Scholar · View at Scopus