Curcumin Induces Nrf2 Nuclear Translocation and Prevents Glomerular Hypertension, Hyperfiltration, Oxidant Stress, and the Decrease in Antioxidant Enzymes in 5/6 Nephrectomized Rats

Figure 2

Curcumin (60 mg/kg/day) ameliorated 5/6NX-induced alterations in renal hemodynamics at the end of the study (day 30): (a) mean arterial pressure (MAP), (b) single-nephron glomerular filtration rate (SNGFR), (c) single-nephron plasma flow (Qa), (d) glomerular capillary pressure (P_GC), (e) stop-flow pressure (SFP) and (f) hydrostatic pressure gradient (ΔP), (g) afferent resistance (AR), and (h) efferent resistance (ER), and (i) glomerular filtration rate (GFR) observed in 5/6NX rats was prevented by curcumin (5/6NX+CUR group). Data are mean ± SEM, 𝑛=8−10. Two-way ANOVA followed by Bonferroni. *𝑃<0.05 versus Control, **𝑃<0.05 versus 5/6NX.

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