Study of the Effects of Total Flavonoids of Astragalus on Atherosclerosis Formation and Potential Mechanisms

Table 1

Effect of TFA and combination vitamins on lipid profiles in cholesterol-fed rabbits (mmol/L).

Groups	Week 0
	TC	HDL-C	LDL-C	TG
A	0.83±0.34	0.46±0.26	0.22±0.15	0.69±0.15
B	0.77±0.35	0.55±0.23	0.30±0.23	0.71±0.23
C	0.81±0.27	0.53±0.27	0.27±0.16	0.53±0.12
D	0.88±0.35	0.49±0.19	0.29±0.23	0.63±0.19
E	0.80±0.23	0.48±0.16	0.22±0.12	0.43±0.19
Groups	Week 4
	TC	HDL-C	LDL-C	TG
A	0.82±0.37	0.35±0.11	0.18±0.11	0.49±0.15
B	34.36±12.94^▾	0.76±0.39^▲	30.91±9.53^▾	1.20±0.62
C	15.06±11.50^▾‡	0.81±0.35^Δ	14.48±10.73^Δ‡	0.79±0.35
D	23.96±9.61^▾	0.67±0.19	21.97±9.06^▾	0.86±0.47
E	12.73±4.96^▾‡	0.55±0.12	12.85±5.15^▴‡	0.89±0.27
Groups	Week 8
	TC	HDL-C	LDL-C	TG
A	0.76±0.34	0.42±0.23	0.22±0.11	0.53±0.19
B	36.55±18.86^▾	0.71±0.39	43.14±17.08^▾	1.52±0.97^▲
C	26.04±17.39^▾	1.34±1.20	27.47±21.11^▾	1.25±0.47^▲
D	29.55±14.49^▾	0.72±0.23	27.18±13.87^▾	1.05±0.39^▲
E	22.16±13.52^▾	0.90±0.43	21.54±9.33^▾∗	1.36±0.78^▲
Groups	Week 12
	TC	HDL-C	LDL-C	TG
A	0.81±0.34	0.40±0.11	0.24±0.15	0.52±0.34
B	57.14±14.18^▾	0.86±0.31	46.02±23.55^▾	2.39±2.09^Δ
C	31.55±15.88^▾†	1.77±0.62	35.30±18.28^▾	1.77±0.81^▴∗
D	37.57±16.96^▾∗	1.37±1.36	35.70±17.31^▾	2.21±1.12^▲
E	37.92±19.25^▾∗	2.35±1.36^∆†	37.14±18.55^▾	2.08±0.97^▲

Group A (𝑛=14) received normal chow; group B (𝑛=15) high-cholesterol diet; group C (𝑛=15) high-cholesterol diet plus vitamin E+C; group D and E (𝑛=15 each) high-cholesterol diet plus TFA (60 or 120 mg/day, resp.). Data expressed asmean±SD. ^Δ𝑃<0.01, ^▾𝑃<0.001 compared with group A. ^∗𝑃<0.05, ^†𝑃<0.05, ^‡𝑃<0.01 compared with group B.