Oxidative Medicine and Cellular Longevity / 2012 / Article / Fig 2

Review Article

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation

Figure 2

PARP1, some interaction partners, and their role in genomic maintenance. ATM indicates ataxia telangiectasia mutated; Bub3, budding uninhibited by benzimidazoles 2; Cenpa/b, centromeric protein a/b; CSB, Cockayne syndrome type B; DEK, DEK oncogene; DNA-Polβ, DNA polymerase β; DNA-PKCS, DNA-activated protein kinase catalytic subunit; HMGB1, high mobility group box 1; Ku70/80, Ku antigens 70/80 kDa subunit; MRE11, meiotic recombination 11; p21, cyclin-dependent kinase inhibitor 1A; p53, tumor suppressor protein p53; PCNA, proliferating cell nuclear antigen; TRF2, telomeric repeat binding factor 2; WRN, Werner syndrome protein; XRCC1, X-ray repair complementing defective in Chinese hamster 1; XPA, xeroderma pigmentosum complementation group A.
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