Ginkgo Biloba Extract EGB761 Protects against Aging-Associated Diastolic Dysfunction in Cardiomyocytes of D-Galactose-Induced Aging Rat

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Group</td><td align="center">SERCA2a activity <br/> (<i>μ</i>mol/g/min)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Control</td><td align="center"><span style="width: 74.362503px;"><svg height="11.4" id="M52" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 74.362503 11.4" width="74.362503" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.963)"><use xlink:href="#x32"></use></g><g transform="matrix(.017,-0,0,-.017,8.222,10.963)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,12.098,10.963)"><use xlink:href="#x36"></use></g><g transform="matrix(.017,-0,0,-.017,20.257,10.963)"><use xlink:href="#x38"></use></g><g transform="matrix(.017,-0,0,-.017,32.19,10.963)"><use xlink:href="#xB1"></use></g><g transform="matrix(.017,-0,0,-.017,45.942,10.963)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,54.102,10.963)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,57.977,10.963)"><use xlink:href="#x33"></use></g><g transform="matrix(.017,-0,0,-.017,66.137,10.963)"><use xlink:href="#x35"></use></g>
</svg></span></td></tr><tr><td align="left">5 g·L<sup>−1</sup> D-galactose</td><td align="center"><span style="width: 80.212502px;"><svg height="14" id="M53" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 80.212502 14" width="80.212502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,13.562)"><use xlink:href="#x31"></use></g><g transform="matrix(.017,-0,0,-.017,8.222,13.562)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,12.098,13.562)"><use xlink:href="#x36"></use></g><g transform="matrix(.017,-0,0,-.017,20.257,13.562)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,32.19,13.562)"><use xlink:href="#xB1"></use></g><g transform="matrix(.017,-0,0,-.017,45.942,13.562)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,54.102,13.562)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,57.977,13.562)"><use xlink:href="#x32"></use></g><g transform="matrix(.017,-0,0,-.017,66.137,13.562)"><use xlink:href="#x38"></use></g>
<g transform="matrix(.012,-0,0,-.012,74.3,5.4)"><use xlink:href="#x61"></use></g>
</svg></span></td></tr><tr><td align="left">5 g·L<sup>−1</sup> D-galactose + 20 <i>μ</i>g·mL<sup>−1</sup> EGB761</td><td align="center"><span style="width: 81.037498px;"><svg height="17.125" id="M54" style="vertical-align:-0.3003pt" version="1.1" viewbox="0 0 81.037498 17.125" width="81.037498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,16.7)"><use xlink:href="#x32"></use></g><g transform="matrix(.017,-0,0,-.017,8.222,16.7)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,12.098,16.7)"><use xlink:href="#x34"></use></g><g transform="matrix(.017,-0,0,-.017,20.257,16.7)"><use xlink:href="#x33"></use></g><g transform="matrix(.017,-0,0,-.017,32.19,16.7)"><use xlink:href="#xB1"></use></g><g transform="matrix(.017,-0,0,-.017,45.942,16.7)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,54.102,16.7)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,57.977,16.7)"><use xlink:href="#x34"></use></g><g transform="matrix(.017,-0,0,-.017,66.137,16.7)"><use xlink:href="#x34"></use></g>
<g transform="matrix(.012,-0,0,-.012,74.3,8.537)"><use xlink:href="#x62"></use></g>
</svg></span></td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>(Data are means ± SD, <svg height="11.225" id="M55" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.963)"><use xlink:href="#x1D45B"></use></g><g transform="matrix(.017,-0,0,-.017,13.305,10.963)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,28.008,10.963)"><use xlink:href="#x36"></use></g>
</svg> experimental replicates, <svg height="13.825" id="M56" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 64.5625 13.825" width="64.5625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,5.4)"><use xlink:href="#x61"></use></g>
<g transform="matrix(.017,-0,0,-.017,5.913,13.562)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,21.432,13.562)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,36.136,13.562)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,44.296,13.562)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,48.171,13.562)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,56.331,13.562)"><use xlink:href="#x35"></use></g>
</svg> versus control group; <svg height="16.9625" id="M57" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 65.375 16.9625" width="65.375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.012,-0,0,-.012,.062,8.537)"><use xlink:href="#x62"></use></g>
<g transform="matrix(.017,-0,0,-.017,6.725,16.7)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,22.262,16.7)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,36.949,16.7)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,45.108,16.7)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,48.984,16.7)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,57.143,16.7)"><use xlink:href="#x35"></use></g>
</svg> versus D-galactose group).<br/></td></tr></table>

Effects of EGB761 on sarcoplasmic reticulum calcium pump (SERCA2a) activity.

Oxidative Medicine and Cellular Longevity

tab3

Table 3

Table 3: Ginkgo Biloba Extract EGB761 Protects against Aging-Associated Diastolic Dysfunction in Cardiomyocytes of D-Galactose-Induced Aging Rat 