Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats
Figure 2
MET reverses the effect of DOX on cardiac GSH level. Rats (/treatment type) received normal saline, DOX in a total cumulative dose of 18 mg/kg, MET (50 or 500 mg/kg, p.o., daily) or DOX plus either dose of MET. 24 h after receiving the last dose of DOX, cardiac tissue level of GSH was determined in rat cardiac tissues. Data are presented as mean ± SEM (). * and # indicate significant change from control and DOX, respectively, at using ANOVA followed by the Tukey-Kramer as a post-ANOVA test.