Desferrioxamine Attenuates Doxorubicin-Induced Acute Cardiotoxicity through TFG-𝜷/Smad p53 Pathway in Rat Model

Table 3

Effect of DOX and DFX on serum cardiac enzyme and isoenzyme levels in rats.

Group	Serum enzyme level
	GOT U/L	LDH IU/L	CK U/L	CK-MB U/L
DOX	118.8±6.4^∗#	541.9±18^∗#	1312.0±67^∗#	325.0±104^∗#
DFX	48.5±4.7	217.0±3.0	298.7±15	202.0±13
DOX + DFX	80.4±7.8	333.0±17	442.2±21	210.0±64
Control	48.1±5.5	249.3±13	296.2±26	169.0±11

Effect of DOX, DFX, and their combination on the serum levels of cardiac enzyme and isoenzyme levels in rats. Data are presented as mean ± SEM (𝑛=10). * and ^# indicate significant change from control and their combination, respectively, at 𝑃<0.05.