The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin

Figure 4

Selected cardiac abnormalities found among the treated animals. (a) Perivascular fibrosis in a rat treated with doxorubicin 1.5 mg/kg (group DOX, van Gieson; objective mag. ×10). (b) Interstitial connective tissue edema in a rat treated with thyroxin dose of 0.2 mg/L (group 0.2T₄; H&E objective mag. ×10). (c) Focal vacuolization of sparse cardiomyocytes in a rat treated with 0.2 mg/L of thyroxin and 1.5 mg/kg of doxorubicin (group 0.2T₄+ DOX; H&E, objective mag. ×20). (d) Sparse and small accumulations of mononuclear cells in myocardium in a rat treated with 0.2 mg/L of thyroxin and 1.5 mg/kg of doxorubicin (group 0.2T₄+ DOX; H&E, objective mag. ×20).

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