Schizandrin, an Antioxidant Lignan from Schisandra chinensis, Ameliorates Aβ_1–42-Induced Memory Impairment in Mice

Table 2

Effects of SCH on SOD, GSH-px activities; MDA, GSH, GSSG levels and GSH/GSSG ratio in the cerebral cortex or hippocampus of Aβ _1–42-induced memory impairment in mice.

Group	Dose (mg/kg)	SOD	MDA	GSH-px	GSH	GSSG	GSH/GSSG
		(U/mg protein)	(nmol/mg protein)	(U/mg protein)	(𝜇mol/L)	(𝜇mol/L)
		Cerebral cortex	Cerebral cortex	Hippocampus	Hippocampus	Hippocampus	Hippocampus
Sham	—	9.99 ± 0.71	6.93 ± 0.77	20.34 ± 1.37	260.63 ± 19.29	94.88 ± 5.37	2.79 ± 0.23
Control	—	6.56 ± 0.55^###	10.36 ± 0.8^##	13.99 ± 1.46^###	161.04 ± 9.45^#	122.36 ± 11.55	1.38 ± 0.14^###
DPZ	0.65	8.80 ± 0.32^**	7.56 ± 0.62^*	18.25 ± 0.95^*	220.63 ± 16.74	95.76 ± 2.40	2.31 ± 0.18^***
SCH	4	6.93 ± 0.36	10.81 ± 0.83	13.94 ± 1.36	136.25 ± 14.14	114.08 ± 6.84	1.21 ± 0.14
SCH	12	7.65 ± 0.47	9.66 ± 1.18	13.61 ± 1.00	167.3 ± 11.557	104.54 ± 4.08	1.64 ± 0.16
SCH	36	8.21 ± 0.48^*	7.92 ± 0.57^*	17.70 ± 0.49^*	202.71 ± 10.79	98.52 ± 1.35	2.06 ± 0.12^**

Mice in sham-operated and control groups were treated with distilled water orally (20 mL/kg). Values represented mean ± S.E.M. and analyzed by one-way ANOVA followed by LSD test or Tamhane test for multiple comparisons (𝑛=8-10). ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 compared with the sham-operated group; ^*P < 0.05, ^**P < 0.01, ^***P < 0.01 compared with the control group.