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Oxidative Medicine and Cellular Longevity
Volume 2012 (2012), Article ID 741545, 15 pages
Review Article

Regular Physical Exercise as a Strategy to Improve Antioxidant and Anti-Inflammatory Status: Benefits in Type 2 Diabetes Mellitus

1Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, 3000-354 Coimbra, Portugal
2ESAV, Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal
3Centre for the Study of Education, Technologies and Health, Polytechnic Institute of Viseu, 3504-510 Viseu, Portugal
4Rehabilitation Medicine and Sports Medicine, Medicine Faculty, Coimbra University, 3000-354 Coimbra, Portugal

Received 20 April 2012; Revised 28 June 2012; Accepted 11 July 2012

Academic Editor: Chad M. Kerksick

Copyright © 2012 Edite Teixeira de Lemos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Over the last 30 years the combination of both a sedentary lifestyle and excessive food availability has led to a significant increase in the prevalence of obesity and aggravation of rates of metabolic syndrome and type 2 diabetes mellitus (T2DM). Several lines of scientific evidence have been demonstrating that a low level of physical activity and decreased daily energy expenditure leads to the accumulation of visceral fat and, consequently, the activation of the oxidative stress/inflammation cascade, which underlies the development of insulin resistant T2DM and evolution of micro, and macrovascular complications. This paper focuses on the pathophysiological pathways associated with the involvement of oxidative stress and inflammation in the development of T2DM and the impact of regular physical exercise (training) as a natural antioxidant and anti-inflammatory strategy to prevent evolution of T2DM and its serious complications.