Inhibition of Mitochondrial Cytochrome c Release and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts

Figure 1

Morphological changes in HDFs in culture (a). Senescence-associated β-galactosidase staining. Positive blue stains of SA β-gal appeared in SIPS and control senescent HDFs as indicated by arrows. Micrographs are shown at 100x magnification (b). Quantitative analysis of positive β-galactosidase stained cells (c). Data are expressed as means ± SD, 𝑛=6. ^adenotes 𝑃<0.05 compared to control young.

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(b)

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