Heterogeneous Responses to Antioxidants in Noradrenergic Neurons
of the Locus Coeruleus Indicate Differing Susceptibility to Free Radical Content
Figure 1
Impact of Trolox treatment on pacemaker activity in LC neurons. (a) Table demonstrating the effect of 100 μM Trolox on the spontaneous firing of LC neurons and comparison of values obtained for action potentials (APs) before (ACSF) and 180 s after 100 μM Trolox treatment ( for spontaneous firing and for AP comparison). (b) Comparison of the waveshape of averaged APs before (ACSF) and 180 s after application of 100 μM Trolox in ACSF (). Hyperpolarizing group was excluded from comparison demonstrated in a and b due to lack of APs at 180 s treatment. (c) and (d) Recordings demonstrating opposite effects induced by 100 μM Trolox which in a small number of cases depolarized neurons and increased firing (c) or hyperpolarized neurons which led to abolition of AP firing (d) (). AP firing recommenced in response to depolarization induced by current injection (d, Arrow).
