Research Article
Simvastatin Attenuates Contrast-Induced Nephropathy through Modulation of Oxidative Stress, Proinflammatory Myeloperoxidase, and Nitric Oxide
Table 1
Drug treatment protocol.
| | Groups | Day 0 | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 |
| | Control (G-1) | WD | Saline | Saline | — | — | Sacrificed | | Glycerol (G-2) | WD | Gly + | Saline | — | — | Sacrificed | | CM + Gly (G-3) | WD | Gly | CM | — | — | Sacrificed | | CM + Gly + SSTN 15 (G-4) | WD | Gly + SSTN | CM + SSTN | SSTN | SSTN | Sacrificed | | CM + Gly + SSTN 30 (G-5) | WD | Gly + SSTN | CM + SSTN | SSTN | SSTN | Sacrificed | | CM + Gly + SSTN 60 (G-6) | WD | Gly + SSTN | CM + SSTN | SSTN | SSTN | Sacrificed | | SSTN 60 (G-7) | WD | SSTN | SSTN | SSTN | SSTN | Sacrificed |
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Abbreviations: WD (Water deprived), Gly (Glycerol), CM (Contrast Media), and SSTN (Simvastatin).
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