Figure 2: Cellular localization and functional grouping of modified proteins identified during aging and age-related diseases. (a) Primary subcellular location of the identified modified proteins. (b) Functional grouping of modified proteins through the use of Ingenuity Pathways Analysis. The bars represent the biological functions identified, named in the -axis. The dotted line represents the threshold above which there are statistically significantly more genes in a biological function than expected by chance.