Quercetin and Sesamin Protect Dopaminergic Cells from MPP⁺-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System

Figure 3

(a) Histogram of kinetic studies showing iNOS protein expression for 24 h in neuronal PC12 cells as revealed by western blotting. Ctrl represents 100% of the controls for each time period. (b) iNOS protein expression after MPP⁺ administration with or without sesamin or quercetin. Quercetin or sesamin alone did not alter iNOS protein expression, whereas MPP⁺ increased iNOS protein levels by 79% in our cellular paradigm. When sesamin or quercetin was administered prior to MPP⁺, a significant decline of iNOS was detected. ***𝑃<0.001 and *𝑃<0.05 versus Ctrl; ^◊◊𝑃<0.01 versus MPP⁺, as determined by 1-way ANOVA, followed by Tukey’s multiple comparison test.

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