Research Article

Association of Base Excision Repair Gene Polymorphisms with ESRD Risk in a Chinese Population

Table 2

Genotypes of OGG1, MTH1, and MUTYH and the risk for HD.

Patients ( )Controls ( )P valueaOR (95%CI)

OGG1 c.977 C > G0. 394
 CC56 (16. 6%)77 (19.1%)
 CG160 (47.5%)200 (49.5%)
 GG121 (35.9%)127 (31.4%)0.1991.22 (0.90–1.66)
 CC or CGb216 (64.1%)277 (68.6%)1.00
 C allele0.4040.4381.00
 G allele0.5960.5620.1801.15 (0.94–1.42)

MTH1 c.247 G > A0.444
 GG316 (93.8%)373 (92.3%)1.00
 GA21 (6.2%)31 (7.7%)
 AA00
 GA or AAb21 (6.2%)31 (7.7%)0.4440.80 (0.45–1.42)
 G allele0.9690.9621.00
 A allele0.0310.0380.4530.81 (0.46–1.42)

MUTYH c.972 G > C0.046
 CC44 (13.1%)63 (15.6%)
 CG155 (46.0%)211 (52.2%)
 GG138 (40.9%)130 (32.2%)0.0131.46 (1.08–1.98)
 CC or CGb199 (59.1%)274 (67.8%)1.00
 C allele0.3610.4171.00
 G allele0.6390.5830.0261.27 (1.03–1.57)

AluYb8MUTYH 0.099
A/A 101 (30.0%)151 (37.4%)1.00
A/P 164 (48.7%)172 (42.6%)
P/P 72 (21.3%)81 (20.0%)
A/P or P/P b236 (70.0%)253 (62.6%)0.0341.40 (1.03–1.90)
A allele0.5430.5871.00
P allele0.4570.4130.0921.19 (0.97–1.47)

Note: CI: confidence interval; OR: odds ratio. value for comparison using χ 2 test to assess correlation between HD risk and predicted high-risk OGG1, MTH1, and MUTYH genotypes and alleles; genotypes were combined properly to assess their association with HD and the genotype 1.00 as the reference category.