Association of Base Excision Repair Gene Polymorphisms with ESRD Risk in a Chinese Population
Table 2
Genotypes of OGG1, MTH1, and MUTYH and the risk for HD.
Patients ()
Controls ()
P valuea
OR (95%CI)
OGG1 c.977 C > G
0. 394
CC
56 (16. 6%)
77 (19.1%)
CG
160 (47.5%)
200 (49.5%)
GG
121 (35.9%)
127 (31.4%)
0.199
1.22 (0.90–1.66)
CC or CGb
216 (64.1%)
277 (68.6%)
1.00
C allele
0.404
0.438
1.00
G allele
0.596
0.562
0.180
1.15 (0.94–1.42)
MTH1 c.247 G > A
0.444
GG
316 (93.8%)
373 (92.3%)
1.00
GA
21 (6.2%)
31 (7.7%)
AA
0
0
GA or AAb
21 (6.2%)
31 (7.7%)
0.444
0.80 (0.45–1.42)
G allele
0.969
0.962
1.00
A allele
0.031
0.038
0.453
0.81 (0.46–1.42)
MUTYH c.972 G > C
0.046
CC
44 (13.1%)
63 (15.6%)
CG
155 (46.0%)
211 (52.2%)
GG
138 (40.9%)
130 (32.2%)
0.013
1.46 (1.08–1.98)
CC or CGb
199 (59.1%)
274 (67.8%)
1.00
C allele
0.361
0.417
1.00
G allele
0.639
0.583
0.026
1.27 (1.03–1.57)
AluYb8MUTYH
0.099
A/A
101 (30.0%)
151 (37.4%)
1.00
A/P
164 (48.7%)
172 (42.6%)
P/P
72 (21.3%)
81 (20.0%)
A/P or P/P b
236 (70.0%)
253 (62.6%)
0.034
1.40 (1.03–1.90)
A allele
0.543
0.587
1.00
P allele
0.457
0.413
0.092
1.19 (0.97–1.47)
Note: CI: confidence interval; OR: odds ratio. value for comparison using χ 2 test to assess correlation between HD risk and predicted high-risk OGG1, MTH1, and MUTYH genotypes and alleles; genotypes were combined properly to assess their association with HD and the genotype 1.00 as the reference category.