Oxidative Medicine and Cellular Longevity

Research Article

Association of Base Excision Repair Gene Polymorphisms with ESRD Risk in a Chinese Population

Table 3

Combined analysis of genetic polymorphisms in OGG1 and MUTYH with HD risk.


Genotypes	Patients ()	Controls ()	P value^c	OR (95% CI)

MUTYH c.972GG^a
OGG1
c.977CC	23 (6.8%)	27 (6.7%)	0.939	1.02 (0.58–1.82)
c.977CG	67 (19.9%)	75 (18.6%)	0.650	1.09 (0.75–1.57)
c.977GG	48 (14.2%)	28 (6.9%)	0.001	2.23 (1.37–3.64)
AluYb8MUTYH
A/A	18 (5.3%)	19 (4.7%)	0.691	1.14 (0.59–2.22)
A/P	58 (17.2%)	54 (13.4%)	0.146	1.35 (0.90–2.02)
P/P	62 (18.4%)	57 (14.1%)	0.113	1.37 (0.93–2.03)

AluYb8MUTYHA/P or P/P ^b
OGG1
c.977CC	38 (11.3%)	42 (10.4%)	0.701	1.10 (0.69–1.74)
c.977CG	120 (35.6%)	136 (33.7%)	0.579	1.09 (0.80–1.48)
c.977GG	78 (23.1%)	75 (18.6%)	0.125	1.32 (0.93–1.89)
MUTYH
c.972CC	11 (3.3%)	12 (3.0%)	0.818	1.10 (0.48–2.53)
c.972CG	105 (31.2%)	130 (32.2%)	0.766	0.95 (0.70–1.30)
c.972GG	120 (35.6%)	111 (27.5%)	0.017	1.46 (1.07–1.99)

Note: CI: confidence interval; OR: odds ratio. Trend test assessing correlation between HD risk and predicted high-risk OGG1 and MUTYH genotypes combined with the MUTYH c.972GG genotype. Trend test assessing correlation between HD risk and predicted high-risk OGG1 and MUTYH genotypes combined with the AluYb8MUTYH A/P or P/P genotype. c: value for comparison using χ ²-test between patients and controls.