Research Article

Astragaloside IV Inhibits Oxidative Stress-Induced Mitochondrial Permeability Transition Pore Opening by Inactivating GSK-3 via Nitric Oxide in H9c2 Cardiac Cells

Figure 3

Confocal fluorescence images of TMRE at baseline and 20 min after exposure to 500 μM H2O2 in H9c2 cells. (a) Astragaloside IV (20~100 μM) prevented oxidant-induced TMRE fluorescence reduction in a dose-dependent manner. (b) Summarized data for TMRE fluorescence intensity measured with confocal microscopy 20 min after exposure to H2O2 expressed as a percentage of baseline. Data are mean ± SD for 8 independent experiments performed in duplicate. * compared to control group (t-test).
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(a)
935738.fig.003b
(b)