Group VIB Phospholipase A2 Promotes Proliferation of INS-1 Insulinoma Cells and Attenuates Lipid Peroxidation and Apoptosis Induced by Inflammatory Cytokines and Oxidant Agents
Figure 5
Influence of inflammatory cytokines and oxidant agents on lipid peroxidation of INS-1 Cell Lines. Control INS-1 cells (light bars) or iPLA2γ-Knockdown INS-1 cells (dark bars) were incubated with vehicle only or with the combination of IL-1β (5 ng/mL) and IFN-γ (80 ng/mL) or with STZ (5 mM) or TBHP (50 μM) for 16 hr, and lipid peroxidation was then determined by the TBARS assay, as described in Experimental Procedures. Mean values ± SEM () are displayed, and an asterisk (*) indicates a significant difference () from control INS-1 cells. An (X) indicates a significant difference () from the vehicle-treated condition.
