Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease

<table>Effect of hesperidin on rotenone-induced cyt c and caspases 3 and 9 expressions in SK-N-SH cells. Rotenone (100 nM) significantly enhanced the expressions of cyt c, caspases 3 and 9, while hesperidin (20 <i>μ</i>g) pretreatment significantly diminished the expressions of cyt c, caspases 3 and 9 in rotenone-treated SK-N-SH cells ((a), (b), and (c)). Western blot data are quantified by using <i>β</i>-actin as an internal control, and the values are expressed as arbitrary units and given as mean ± SD of four experiments in each group. <svg height="13.95" id="M25" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to control, <svg height="15.775" id="M26" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to rotenone groups.</table>

Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease 

Figure 7 | Neuroprotective Effects of Hesperidin, a Plant Flavanone, on Rotenone-Induced Oxidative Stress and Apoptosis in a Cellular Model for Parkinson’s Disease 