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Oxidative Medicine and Cellular Longevity
Volume 2013, Article ID 126083, 6 pages
Research Article

Transient Acidosis during Early Reperfusion Attenuates Myocardium Ischemia Reperfusion Injury via PI3k-Akt-eNOS Signaling Pathway

1Department of Anesthesiology, Chongqing Zhoushan Hospital, Chongqing 404100, China
2Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 404100, China
3Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430000, China
4Department of Cardiac Surgery, Chongqing Zhoushan Hospital, Chongqing 404100, China
5Department of Cardiac Surgery, Sun Yat-sen Cardiovascular Hospital, Shenzhen 515100, China

Received 9 August 2013; Accepted 25 September 2013

Academic Editor: Zhengyuan Xia

Copyright © 2013 Xin Qiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In this paper, we concluded that transient acidosis reperfusion conferred cardioprotection against myocardial ischemia reperfusion injury in isolated rat hearts through activating PI3K-Akt-eNOS pathway.