Blocking Type I Interferon Signaling Rescues Lymphocytes from Oxidative Stress, Exhaustion, and Apoptosis in a Streptozotocin-Induced Mouse Model of Type I Diabetes

Figure 2

Plasma levels of proinflammatory cytokines are altered during diabetes. The levels of plasma cytokines (IL-1α, IL-1β, IL-6, and CXCL10) were measured in the three groups of mice using an ELISA. The results are presented as the picograms of cytokine per milliliter of plasma and are expressed as the mean ± SEM (𝑛=10). *𝑃<0.05 for diabetic versus control; ^#𝑃<0.05 for diabetic + anti-IFNAR1 versus diabetic; ⁺𝑃<0.05 for diabetic + anti-IFNAR1 versus control.