Research Article

Blocking Type I Interferon Signaling Rescues Lymphocytes from Oxidative Stress, Exhaustion, and Apoptosis in a Streptozotocin-Induced Mouse Model of Type I Diabetes

Table 1

Induction of diabetes mediates elevated levels of plasma oxidative stress. Blood biochemical parameters were measured in the three groups of mice, and the results are presented as the means ± SEM ( ), as described in Section 2.

ParametersControl miceDiabetic miceDiabetic + anti-IFNAR1 mice

Glucose (mg/dl)124 ± 9.3332 ± 23*301 ± 24+
Insulin (ng/mL)5 ± 0.21.9 ± 0.1*3.9 ± 0.35+
ROS (nmol/mL)17 ± 3.665 ± 4.9*29 ± 3.9#+
Hydroperoxide (mg/100 mL)22 ± 4.754 ± 5.1*34 ± 3.8#+
MDA (nmol/mL)2.1 ± 0.68.1 ± 0.9*4.1 ± 0.45#+
IFN-α (ng/mL)1.722 ± 0.213.858 ± 0.586*2.284 ± 0.264#+
IFN-β (ng/mL)0.911 ± 0.192.97 ± 0.27*1.72 ± 0.18#+

for diabetic versus control; # for diabetic + anti-IFNAR1 versus diabetic; + for diabetic + anti-IFNAR1 versus control.