Resolvin D1 Reverts Lipopolysaccharide-Induced TJ Proteins Disruption and the Increase of Cellular Permeability by Regulating I κBα Signaling in Human Vascular Endothelial Cells

Figure 4

Effects of ERK1/2 and NF-κB inhibitors on the expression of zo-1 and occludin in HUVECs. The protein expression of zo-1 (a) and occludin (b) were detected by western blotting. Densitometric analysis of the protein levels of zo-1 and occludin were shown (𝑛=3). Data was expressed as mean ± s.e.m. ^∗∗𝑃<0.01, ^∗𝑃<0.05 versus LPS group; ^##𝑃<0.01, ^#𝑃<0.05 versus control group; ^&&𝑃<0.01, ^&𝑃<0.05 versus RvD1 + LPS group.

(a)

(b)